Liothyronine is a T3 thyroid hormone that is normally produced by the thyroid gland in a ratio of 4:1 to T4:T3. liothyronine sodium is the active form of thyroxine that is composed in a basic chemical structure of a tyrosine with bound iodine. The exogenous product liothyronine was developed by King Pharmaceuticals and approved by the FDA in 1956.
Liothyronine is officially approved for the following indications:
Replacement therapy for congenital or acquired primary (thyroid), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism.
As an adjunct to surgery and radioactive iodine in the treatment of thyroid cancer.
As a diagnostic agent in tests for suppression of mild hyperthyroidism or thyroid autonomy.
Generally, exogenous dianabol tablets is used to replace insufficient hormone production and restore plasma T3 levels.
Lack of liothyronine can present as a pale and puffy face, coarse and brittle hair, dry skin, a hoarse voice, and constipation, as well as irregular periods, drowsiness, and lethargy.
Liothyronine should never be used in the suppression of benign nodules and diffuse nontoxic goiter in patients with iodine deficiency or in the treatment of hyperthyroidism during the recovery phase of subacute thyroiditis.
As a hormone replacement, boldenone steroid is more potent and faster acting than levothyroxine, but the time of action is significantly shorter. The type of treatment should be carefully assessed since the rapid correction of thyroid hormones in some diseases has additional risks such as heart failure3. The onset of activity is observed within a few hours of administration and the maximum effect is observed after 2-3 days.
Liothyronine treatment has been shown to produce normal plasma levels of T3 hormone but has no effect on plasma T4 concentration.
Mechanism of action
d bol steroid replaces endogenous thyroid hormone and then exerts its physiological effects by controlling DNA transcription and protein synthesis. This effect on DNA is achieved by binding of liothyronine to DNA-bound thyroid receptors. Exogenous liothyronine exerts all the normal effects of endogenous T3 thyroid hormone. Therefore, it increases energy expenditure, accelerates the rate of cell oxidation by stimulating the growth, maturation and metabolism of body tissues, helps myelination of nerves and the development of synaptic processes in the nervous system and improves the carbohydrate and protein metabolism.
Thyroid hormones are well absorbed orally. Of these hormones, liothyronine is anadrol 50 almost completely absorbed, with no change in rate of absorption by concomitant administration of food. 6 hours with an AUC of 4740 ng.h/dL.
Liothyronine shows very high plasma protein binding and approximately 99.7% of the administered dose can be found bound. clenbuterol side effects binds to thyroxine-binding globulin, prethyroxine-binding albumin, and albumin. It is important to note that only the small free part of liothyronine is metabolically active.